| Reaction Details |
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 | Report a problem with these data |
| Target | Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 2 |
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| Ligand | BDBM50385309 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_822727 (CHEMBL2040044) |
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| Ki | >20000±n/a nM |
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| Citation |  Bell, IM; Stump, CA; Gallicchio, SN; Staas, DD; Zartman, CB; Moore, EL; Sain, N; Urban, M; Bruno, JG; Calamari, A; Kemmerer, AL; Mosser, SD; Fandozzi, C; White, RB; Zrada, MM; Selnick, HG; Graham, SL; Vacca, JP; Kane, SA; Salvatore, CA MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats. Bioorg Med Chem Lett22:3941-5 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 2 |
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| Name: | Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 2 |
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| Synonyms: | Adrenomedullin receptor AM1, CALCRL/RAMP2 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 822727 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Receptor activity-modifying protein 2 |
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| Synonyms: | Amylin receptor AMY2, CALCR/RAMP2 | RAMP2 | RAMP2_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 19604.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | EBI_100672 |
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| Residue: | 175 |
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| Sequence: | MASLRVERAGGPRLPRTRVGRPAALRLLLLLGAVLNPHEALAQPLPTTGTPGSEGGTVKN
YETAVQFCWNHYKDQMDPIEKDWCDWAMISRPYSTLRDCLEHFAELFDLGFPNPLAERII
FETHQIHFANCSLVQPTFSDPPEDVLLAMIIAPICLIPFLITLVVWRSKDSEAQA
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| Component 2 |
| Name: | Calcitonin gene-related peptide type 1 receptor |
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| Synonyms: | Adrenomedullin receptor AM1; CALCRL/RAMP2 | CALCRL | CALRL_HUMAN | CGRP type 1 receptor | CGRP type 1 receptor mRNA | CGRPR | Calcitonin gene-related peptide (CGRP) receptor | Calcitonin gene-related peptide 1 (CGRP) | Calcitonin receptor-like receptor | Calcitonin receptor-like receptor (CLR) | Human CL receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 52980.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16602 |
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| Residue: | 461 |
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| Sequence: | MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA
EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT
WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL
FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL
IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA
ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI
AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS
YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
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| BDBM50385309 |
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| n/a |
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| Name | BDBM50385309 |
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| Synonyms: | CHEMBL2035983 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H30F2N6O3 |
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| Mol. Mass. | 572.6051 |
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| SMILES | C[C@]1(CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2C[C@]3(Cc2c1)C(=O)Nc1ncccc31)c1cc(F)cc(F)c1 |r| |
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| Structure | 
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