| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B10 |
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| Ligand | BDBM16452 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_823524 (CHEMBL2045967) |
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| IC50 | 2360±n/a nM |
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| Citation |  Adeniji, AO; Twenter, BM; Byrns, MC; Jin, Y; Chen, M; Winkler, JD; Penning, TM Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17ß-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships. J Med Chem55:2311-23 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member B10 |
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| Name: | Aldo-keto reductase family 1 member B10 |
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| Synonyms: | AK1BA_HUMAN | AKR1B10 | AKR1B11 | ARL-1 | ARP | Aldo-keto reductase family 1 member B10 | Aldo-keto reductase family 1 member B10 (AKR1B10) | Aldo-keto reductase family member 1B10 (AKR1B10) | Aldose reductase-like | Aldose reductase-related protein | SI reductase | Small intestine reductase | hARP |
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| Type: | Protein |
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| Mol. Mass.: | 36024.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60218. 1ZUA; 4JII; 4GQ0 |
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| Residue: | 316 |
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| Sequence: | MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQ
EKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGD
DLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKP
VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK
HKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACN
VLQSSHLEDYPFNAEY
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| BDBM16452 |
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| n/a |
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| Name | BDBM16452 |
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| Synonyms: | (4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-3,4-dihydrophthalazin-1-yl)acetic acid | 2-(4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-3,4-dihydrophthalazin-1-yl)acetic acid | Alond | CHEMBL10372 | Xedia | Zopolrestat |
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| Type | Small organic molecule |
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| Emp. Form. | C19H12F3N3O3S |
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| Mol. Mass. | 419.377 |
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| SMILES | OC(=O)Cc1nn(Cc2nc3cc(ccc3s2)C(F)(F)F)c(=O)c2ccccc12 |
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| Structure | 
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