| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nitric oxide synthase, inducible |
|---|
| Ligand | BDBM50386178 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_824674 (CHEMBL2045839) |
|---|
| Ki | 1.8±n/a nM |
|---|
| Citation |  Pozo-Rodrigálvarez, A; Gradillas, A; Serrano, J; Fernández, AP; Martínez-Murillo, R; Pérez-Castells, J New synthesis and promising neuroprotective role in experimental ischemic stroke of ONO-1714. Eur J Med Chem54:439-46 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nitric oxide synthase, inducible |
|---|
| Name: | Nitric oxide synthase, inducible |
|---|
| Synonyms: | HEP-NOS | Hepatocyte NOS | Inducible NO synthase | Inducible NOS | NOS type II | NOS2 | NOS2A | NOS2_HUMAN | Nitric oxide synthase, inducible (iNOS) | iNOS |
|---|
| Type: | Homodimer |
|---|
| Mol. Mass.: | 131141.95 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P35228 |
|---|
| Residue: | 1153 |
|---|
| Sequence: | MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLSKQQNESPQPL
VETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIM
TPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQ
LTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNI
RSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYG
RFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVG
GLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINI
AVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEM
LNYVLSPFYYYQVEAWKTHVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVT
ILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPG
NGEKLKKSLFMLKELNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGD
ELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHHYRLVQDSQPLDL
SKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQ
PALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQ
LLLQKLAQVATEEPERQRLEALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQL
PILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDPVPCF
VRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRRPD
EDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGHLY
VCGDVRMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFGAVFPYEAKKDR
VAVQPSSLEMSAL
|
|
|
|---|
| BDBM50386178 |
|---|
| n/a |
|---|
| Name | BDBM50386178 |
|---|
| Synonyms: | CHEMBL1800346 | ONO-1714 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C7H11ClN2 |
|---|
| Mol. Mass. | 158.629 |
|---|
| SMILES | C[C@H]1CC(N)=N[C@@H]2[C@H](Cl)[C@H]12 |r,c:4| |
|---|
| Structure | 
|
|---|
Search and Browse
