| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50386352 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_826696 (CHEMBL2051143) |
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| Ki | 44±n/a nM |
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| Citation |  Rao, AU; Shao, N; Aslanian, RG; Chan, TY; Degrado, SJ; Wang, L; McKittrick, B; Senior, M; West, RE; Williams, SM; Wu, RL; Hwa, J; Patel, B; Zheng, S; Sondey, C; Palani, A Discovery of a potent thiadiazole class of histamine h3 receptor antagonist for the treatment of diabetes. ACS Med Chem Lett3:198-202 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | HH3R | HRH3_MOUSE | Hrh3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48560.37 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_988451 |
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| Residue: | 445 |
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| Sequence: | MERAPPDGLMNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVETGEAGLGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
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| BDBM50386352 |
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| n/a |
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| Name | BDBM50386352 |
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| Synonyms: | CHEMBL2048588 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H29N7S |
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| Mol. Mass. | 411.567 |
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| SMILES | C1CCN(CC1)C1CCN(CC1)c1nnc(s1)N1CCC=C(C1)c1ncccn1 |c:23| |
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| Structure | 
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