Reaction Details |
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Target | Tyrosine-protein kinase ZAP-70 |
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Ligand | BDBM50386693 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_826399 (CHEMBL2049410) |
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IC50 | >10000±n/a nM |
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Citation | Kawakita, Y; Banno, H; Ohashi, T; Tamura, T; Yusa, T; Nakayama, A; Miki, H; Iwata, H; Kamiguchi, H; Tanaka, T; Habuka, N; Sogabe, S; Ohta, Y; Ishikawa, T Design and synthesis of pyrrolo[3,2-d]pyrimidine human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors: exploration of novel back-pocket binders. J Med Chem55:3975-91 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase ZAP-70 |
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Name: | Tyrosine-protein kinase ZAP-70 |
Synonyms: | 70 kDa zeta-associated protein | SRK | Syk-related tyrosine kinase | Tyrosine Kinase ZAP-70 | Tyrosine-protein kinase ZAP-70 | Tyrosine-protein kinase ZAP-70 (Syk) | Tyrosine-protein kinase ZAP-70 (ZAP70) | Tyrosine-protein kinase ZAP70 | ZAP70 | ZAP70_HUMAN | Zeta-chain (TCR) associated protein kinase 70kDa |
Type: | Enzyme |
Mol. Mass.: | 69881.61 |
Organism: | Homo sapiens (Human) |
Description: | ZAP-70 SH2 domain was expressed and purified from E. coli using O-phospho-L-tyrosine-agarose column. |
Residue: | 619 |
Sequence: | MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP
IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD
AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG
AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK
LKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARIT
SPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR
KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGG
PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDF
GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY
KKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL
ASKVEGPPGSTQKAEAACA
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BDBM50386693 |
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n/a |
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Name | BDBM50386693 |
Synonyms: | CHEMBL2048912 |
Type | Small organic molecule |
Emp. Form. | C25H24ClN7O2S |
Mol. Mass. | 522.022 |
SMILES | CC(C)(N)C(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4cccc5sncc45)c(Cl)c3)c12 |
Structure |
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