| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen synthase kinase-3 beta |
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| Ligand | BDBM50386933 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_827456 (CHEMBL2051313) |
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| EC50 | 1.5±n/a nM |
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| Citation |  Lee, SC; Kim, HT; Park, CH; Lee, do Y; Chang, HJ; Park, S; Cho, JM; Ro, S; Suh, YG Design, synthesis and biological evaluation of novel imidazopyridines as potential antidiabetic GSK3ß inhibitors. Bioorg Med Chem Lett22:4221-4 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen synthase kinase-3 beta |
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| Name: | Glycogen synthase kinase-3 beta |
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| Synonyms: | GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B |
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| Type: | Enzyme |
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| Mol. Mass.: | 46756.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49841 |
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| Residue: | 420 |
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| Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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| BDBM50386933 |
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| n/a |
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| Name | BDBM50386933 |
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| Synonyms: | CHEMBL2048678 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16FN5O2 |
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| Mol. Mass. | 377.3717 |
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| SMILES | CCOc1ccncc1NC(=O)c1ccnc2nc([nH]c12)-c1ccc(F)cc1 |
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| Structure | 
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