Reaction Details |
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Target | Hepatocyte growth factor receptor |
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Ligand | BDBM50359981 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_828151 (CHEMBL2049981) |
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IC50 | 200±n/a nM |
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Citation | Colombo, F; Tintori, C; Furlan, A; Borrelli, S; Christodoulou, MS; Dono, R; Maina, F; Botta, M; Amat, M; Bosch, J; Passarella, D 'Click' synthesis of a triazole-based inhibitor of Met functions in cancer cells. Bioorg Med Chem Lett22:4693-6 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hepatocyte growth factor receptor |
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Name: | Hepatocyte growth factor receptor |
Synonyms: | HGF receptor | HGF/SF receptor | MET | MET_CANLF | Proto-oncogene c-Met | SF receptor | Scatter factor receptor |
Type: | PROTEIN |
Mol. Mass.: | 154649.32 |
Organism: | Canis familiaris |
Description: | ChEMBL_828151 |
Residue: | 1382 |
Sequence: | MKAPAVLAPGILVLLFTLVQKSYGECKEALVKSEMNVNMKYQLPNFTAETPIQNVVLHKH
HIYLGAVNYIYVLNDKDLQKVAEYKTGPVLEHPDCSPCQDCSHKANLSGGVWEDNINMAL
LVDTYYDDQLISCGSVHRGTCQRHILPPSNIADIQSEVHCMYSSQADEEPSQCPDCVVSA
LGTKVLISEKDRFINFFVGNTINSSDHPDHSLHSISVRRLKETQDGFKFLTDQSYIDVLP
EFRDSYPIKYVHAFESNHFIYFLTVQRETLDAQTFHTRIIRFCSVDSGLHSYMEMPLECI
LTEKRRKRSTREEVFNILQAAYVSKPGAHLAKQIGANLNDDILYGVFAQSKPDSAEPMNR
SAVCAFPIKYVNEFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARNDEYRTE
FTTALQRVDLFMGQFNQVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGLSTPHVNF
RLDSHPVSPEAIVEHPLNQNGYTLVVTGKKITRIPLNGLGCEHFQSCSQCLSAPPFVQCG
WCHDRCVHLEECPTGAWTQEVCLPAIYEVFPTSAPLEGGTVLTVCGWDFGFRRNNKFDLK
KTKVFLGNESCTLTLSESTTNMLKCTVGPAVNEHFNISIIISNGRGTAQYSTFSYVDPII
TSISPSYGPKNGGTLLTLTGKYLNSGNSRHISMGGKTCTLKSVSDSILECYTPAQATATE
FPIKLKIDLANREMNSFSYQEDPIVYAIHPTKSFISGGSTITAVGKNLNSVSVLRMVIDV
HETRRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGIHSKYFDLIYVHNP
VFKPFEKPVMISIGNENVLEIKGNDIDPEAVKGEVLKVGNKSCETIYSDSKAVLCKVPND
LLKLNNELNIEWKQAVSSTVLGKVIVQPDQNFTGLIAGVISISTIVLLLLGLFLWLKRKK
QIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNG
SCRQVQYPLTDLSPMLTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVH
FNEVIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNV
LSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKK
FVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQK
FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKC
WHPRAELRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSQDNIDGEG
DT
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BDBM50359981 |
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n/a |
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Name | BDBM50359981 |
Synonyms: | CHEMBL1927770 |
Type | Small organic molecule |
Emp. Form. | C34H24F6N4O2S |
Mol. Mass. | 666.635 |
SMILES | FC(F)(F)c1cc(CC(=O)N[C@@H](Cc2ccccc2)C(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2ccccc32)cc(c1)C(F)(F)F |r| |
Structure |
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