| Reaction Details |
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 | Report a problem with these data |
| Target | Hepatocyte growth factor receptor |
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| Ligand | BDBM50359982 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_828151 (CHEMBL2049981) |
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| IC50 | 200±n/a nM |
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| Citation |  Colombo, F; Tintori, C; Furlan, A; Borrelli, S; Christodoulou, MS; Dono, R; Maina, F; Botta, M; Amat, M; Bosch, J; Passarella, D 'Click' synthesis of a triazole-based inhibitor of Met functions in cancer cells. Bioorg Med Chem Lett22:4693-6 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hepatocyte growth factor receptor |
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| Name: | Hepatocyte growth factor receptor |
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| Synonyms: | HGF receptor | HGF/SF receptor | MET | MET_CANLF | Proto-oncogene c-Met | SF receptor | Scatter factor receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 154649.32 |
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| Organism: | Canis familiaris |
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| Description: | ChEMBL_828151 |
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| Residue: | 1382 |
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| Sequence: | MKAPAVLAPGILVLLFTLVQKSYGECKEALVKSEMNVNMKYQLPNFTAETPIQNVVLHKH
HIYLGAVNYIYVLNDKDLQKVAEYKTGPVLEHPDCSPCQDCSHKANLSGGVWEDNINMAL
LVDTYYDDQLISCGSVHRGTCQRHILPPSNIADIQSEVHCMYSSQADEEPSQCPDCVVSA
LGTKVLISEKDRFINFFVGNTINSSDHPDHSLHSISVRRLKETQDGFKFLTDQSYIDVLP
EFRDSYPIKYVHAFESNHFIYFLTVQRETLDAQTFHTRIIRFCSVDSGLHSYMEMPLECI
LTEKRRKRSTREEVFNILQAAYVSKPGAHLAKQIGANLNDDILYGVFAQSKPDSAEPMNR
SAVCAFPIKYVNEFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARNDEYRTE
FTTALQRVDLFMGQFNQVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGLSTPHVNF
RLDSHPVSPEAIVEHPLNQNGYTLVVTGKKITRIPLNGLGCEHFQSCSQCLSAPPFVQCG
WCHDRCVHLEECPTGAWTQEVCLPAIYEVFPTSAPLEGGTVLTVCGWDFGFRRNNKFDLK
KTKVFLGNESCTLTLSESTTNMLKCTVGPAVNEHFNISIIISNGRGTAQYSTFSYVDPII
TSISPSYGPKNGGTLLTLTGKYLNSGNSRHISMGGKTCTLKSVSDSILECYTPAQATATE
FPIKLKIDLANREMNSFSYQEDPIVYAIHPTKSFISGGSTITAVGKNLNSVSVLRMVIDV
HETRRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGIHSKYFDLIYVHNP
VFKPFEKPVMISIGNENVLEIKGNDIDPEAVKGEVLKVGNKSCETIYSDSKAVLCKVPND
LLKLNNELNIEWKQAVSSTVLGKVIVQPDQNFTGLIAGVISISTIVLLLLGLFLWLKRKK
QIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNG
SCRQVQYPLTDLSPMLTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVH
FNEVIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNV
LSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKK
FVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQK
FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKC
WHPRAELRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSQDNIDGEG
DT
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| BDBM50359982 |
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| n/a |
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| Name | BDBM50359982 |
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| Synonyms: | CHEMBL1927771 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H24F6N4O2S |
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| Mol. Mass. | 666.635 |
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| SMILES | FC(F)(F)c1cc(CC(=O)N[C@H](Cc2ccccc2)C(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2ccccc32)cc(c1)C(F)(F)F |r| |
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| Structure | 
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