| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dihydrofolate reductase |
|---|
| Ligand | BDBM50387418 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_828283 (CHEMBL2050302) |
|---|
| IC50 | >16000±n/a nM |
|---|
| Citation |  Gangjee, A; Zhao, Y; Ihnat, MA; Thorpe, JE; Bailey-Downs, LC; Kisliuk, RL Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents. Bioorg Med Chem20:4217-25 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dihydrofolate reductase |
|---|
| Name: | Dihydrofolate reductase |
|---|
| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 21453.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant human DHFR. |
|---|
| Residue: | 187 |
|---|
| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
|
|
|
|---|
| BDBM50387418 |
|---|
| n/a |
|---|
| Name | BDBM50387418 |
|---|
| Synonyms: | CHEMBL2047245 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H20N4 |
|---|
| Mol. Mass. | 316.3996 |
|---|
| SMILES | CC(C)c1ccc(Nc2[nH]c(N)nc3cc4ccccc4c23)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
