| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 1 |
|---|
| Ligand | BDBM50387595 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_830632 (CHEMBL2061525) |
|---|
| IC50 | 3600±n/a nM |
|---|
| Citation |  Hansen, FK; Khankischpur, M; Tolaymat, I; Mesaros, R; Dannhardt, G; Geffken, D Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives. Bioorg Med Chem Lett22:5031-4 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prostaglandin G/H synthase 1 |
|---|
| Name: | Prostaglandin G/H synthase 1 |
|---|
| Synonyms: | COX-1 | COX1 | Cyclooxygenase | Cyclooxygenase-1 | PGH1_BOVIN | PTGS1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 68814.10 |
|---|
| Organism: | Bos taurus |
|---|
| Description: | ChEMBL_547440 |
|---|
| Residue: | 600 |
|---|
| Sequence: | MSRQGISLRFPLLLLLLSPSPVLPADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCT
RTGYYGPNCTIPEIWTWLRTTLRPSPSFVHFLLTHGRWLWDFVNATFIRDKLMRLVLTVR
SNLIPSPPTYNVAHDYISWESFSNVSYYTRILPSVPRDCPTPMGTKGKKQLPDAEFLSRR
FLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLER
QYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMV
YATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLK
FDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVE
ALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRELRLQPFNEYRKRFGMKPYTSFQE
LTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPIC
SPEYWKASTFGGDVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPHREDRPGVERPPTEL
|
|
|
|---|
| BDBM50387595 |
|---|
| n/a |
|---|
| Name | BDBM50387595 |
|---|
| Synonyms: | CHEMBL2057739 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H8O4S |
|---|
| Mol. Mass. | 224.233 |
|---|
| SMILES | COc1cccc2c(O)c(sc12)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
