Reaction Details |
| Report a problem with these data |
Target | 5-lipoxygenase |
---|
Ligand | BDBM50038649 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_830634 (CHEMBL2061527) |
---|
IC50 | 760±n/a nM |
---|
Citation | Hansen, FK; Khankischpur, M; Tolaymat, I; Mesaros, R; Dannhardt, G; Geffken, D Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives. Bioorg Med Chem Lett22:5031-4 (2012) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
5-lipoxygenase |
---|
Name: | 5-lipoxygenase |
Synonyms: | Arachidonate 5-lipoxygenase |
Type: | PROTEIN |
Mol. Mass.: | 49994.23 |
Organism: | Bos taurus |
Description: | ChEMBL_157766 |
Residue: | 430 |
Sequence: | MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDE
ELGDIQLIKIEKRKYWFHDDWYLKYITVKTPCGDYIEFPCYRWISGEGEIVLRDGQAKLA
CDDQIHVLKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVL
NYSKAMENLFINRFMHMFQSSWSDFADFEKIFVRISNTISERVMNHWQEDRMFGYQFLNG
CNPVMIQRCLKLPDNLPVTTEMVECSLERQLTLEQEIEQGNIFIVDFKLLDGIDANKTDP
CTLQFLAAPICLLYKNLANKIVPIAIQLNQVPGEENPIFLPSDAKYDWLLAKIWVRSSDF
HVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICEYG
LFDKANATGG
|
|
|
BDBM50038649 |
---|
n/a |
---|
Name | BDBM50038649 |
Synonyms: | 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetic acid | CHEMBL300982 | Licofelone | ML-3000 | [2-(4-Chloro-phenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl]-acetic acid | [6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZIN-5-YL]ACETIC ACID |
Type | Small organic molecule |
Emp. Form. | C23H22ClNO2 |
Mol. Mass. | 379.879 |
SMILES | CC1(C)Cc2c(c(c(CC(O)=O)n2C1)-c1ccc(Cl)cc1)-c1ccccc1 |
Structure |
|