| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine N-methyltransferase |
|---|
| Ligand | BDBM50041457 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_829172 (CHEMBL2059994) |
|---|
| Ki | 19±n/a nM |
|---|
| Citation |  Lee, SG; Alpert, TD; Jez, JM Crystal structure of phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with amodiaquine. Bioorg Med Chem Lett22:4990-3 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine N-methyltransferase |
|---|
| Name: | Histamine N-methyltransferase |
|---|
| Synonyms: | HMT | HNMT | HNMT_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 33287.63 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_87234 |
|---|
| Residue: | 292 |
|---|
| Sequence: | MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIG
GGAGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAKTSNLENVKFAWHKETS
SEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWD
KLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLL
WDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA
|
|
|
|---|
| BDBM50041457 |
|---|
| n/a |
|---|
| Name | BDBM50041457 |
|---|
| Synonyms: | 4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol | AMODIAQUINE | CHEMBL682 | med.21724, Compound 188 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H22ClN3O |
|---|
| Mol. Mass. | 355.861 |
|---|
| SMILES | CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O |
|---|
| Structure | 
|
|---|
Search and Browse
