| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] A |
|---|
| Ligand | BDBM50321885 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_829593 (CHEMBL2060936) |
|---|
| IC50 | 35±n/a nM |
|---|
| Citation |  Lewellyn, K; Bialonska, D; Chaurasiya, ND; Tekwani, BL; Zjawiony, JK Synthesis and evaluation of aplysinopsin analogs as inhibitors of human monoamine oxidase A and B. Bioorg Med Chem Lett22:4926-9 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Amine oxidase [flavin-containing] A |
|---|
| Name: | Amine oxidase [flavin-containing] A |
|---|
| Synonyms: | AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 59689.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P21397 |
|---|
| Residue: | 527 |
|---|
| Sequence: | MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHV
DYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIA
YLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNI
NVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKL
NHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPM
GAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADR
LAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG
RVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKD
VPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
|
|
|
|---|
| BDBM50321885 |
|---|
| n/a |
|---|
| Name | BDBM50321885 |
|---|
| Synonyms: | (E)-5-((1H-Indol-3yl)methylene)-2-imino-1,3-dimethylimidazolidin-4-one | CHEMBL404232 | aplysinopsin |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H14N4O |
|---|
| Mol. Mass. | 254.2872 |
|---|
| SMILES | CN1C(=N)N(C)\C(=C\c2c[nH]c3ccccc23)C1=O |
|---|
| Structure | 
|
|---|
Search and Browse
