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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase mTOR | ||
| Ligand | BDBM50388106 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_829330 (CHEMBL2060320) | ||
| IC50 | 989±n/a nM | ||
| Citation |  Martínez González, S; Hernández, AI; Varela, C; Lorenzo, M; Ramos-Lima, F; Cendón, E; Cebrián, D; Aguirre, E; Gomez-Casero, E; Albarrán, MI; Alfonso, P; García-Serelde, B; Mateos, G; Oyarzabal, J; Rabal, O; Mulero, F; Gonzalez-Granda, T; Link, W; Fominaya, J; Barbacid, M; Bischoff, JR; Pizcueta, P; Blanco-Aparicio, C; Pastor, J Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR. Bioorg Med Chem Lett22:5208-14 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase mTOR | |||
| Name: | Serine/threonine-protein kinase mTOR | ||
| Synonyms: | FK506-binding protein 12-rapamycin complex-associated protein 1 | FKBP12-rapamycin complex-associated protein | FRAP | FRAP 1 (mTOR) | FRAP1 | FRAP2 | MTOR | MTOR_HUMAN | Mammalian Target of Rapamycin (mTOR) | P42345 | RAFT1 | RAPT1 | Rapamycin and FKBP12 target 1 | Rapamycin target protein | Serine/threonine-protein kinase (mTOR) | mTORC2 | ||
| Type: | Rapamycin target protein | ||
| Mol. Mass.: | 288917.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P42345 | ||
| Residue: | 2549 | ||
| Sequence: |
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| BDBM50388106 | |||
| n/a | |||
| Name | BDBM50388106 | ||
| Synonyms: | CHEMBL2058168 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H26N8O3 | ||
| Mol. Mass. | 438.4829 | ||
| SMILES | Nc1ncc(cn1)-c1cn2cc(nc2c(n1)N1CCOCC1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:28.32,wD:25.28,(-9.8,-30.99,;-8.46,-30.22,;-8.46,-28.68,;-7.13,-27.91,;-5.8,-28.69,;-5.8,-30.22,;-7.12,-31,;-4.47,-27.92,;-3.13,-28.69,;-1.8,-27.92,;-.33,-28.39,;.57,-27.14,;-.33,-25.9,;-1.8,-26.38,;-3.13,-25.61,;-4.47,-26.32,;-3.13,-24.07,;-4.46,-23.31,;-4.46,-21.77,;-3.13,-20.99,;-1.8,-21.77,;-1.8,-23.31,;2.11,-27.14,;2.88,-25.8,;2.89,-28.47,;2.12,-29.81,;.58,-29.81,;-.19,-31.13,;.58,-32.47,;-.2,-33.8,;2.12,-32.47,;2.89,-31.13,)| | ||
| Structure | 
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