| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic initiation factor 4A-I |
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| Ligand | BDBM50388144 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_828665 (CHEMBL2060259) |
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| IC50 | 20±n/a nM |
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| Citation |  Rodrigo, CM; Cencic, R; Roche, SP; Pelletier, J; Porco, JA Synthesis of rocaglamide hydroxamates and related compounds as eukaryotic translation inhibitors: synthetic and biological studies. J Med Chem55:558-62 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Eukaryotic initiation factor 4A-I |
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| Name: | Eukaryotic initiation factor 4A-I |
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| Synonyms: | ATP-dependent RNA helicase eIF4A-1 | DDX2A | EIF4A | EIF4A1 | IF4A1_HUMAN | eIF-4A-I | eIF4A-I |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46146.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_864983 |
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| Residue: | 406 |
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| Sequence: | MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ
RAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVV
MALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFV
LDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE
LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS
AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI
GRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
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| BDBM50388144 |
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| n/a |
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| Name | BDBM50388144 |
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| Synonyms: | CHEMBL2058177 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H29NO8 |
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| Mol. Mass. | 507.5318 |
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| SMILES | CONC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(OC)cc3OC |r| |
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| Structure | 
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