Reaction Details |
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Target | Eukaryotic initiation factor 4A-I |
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Ligand | BDBM50388144 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_828664 (CHEMBL2060258) |
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IC50 | 0.5±n/a nM |
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Citation | Rodrigo, CM; Cencic, R; Roche, SP; Pelletier, J; Porco, JA Synthesis of rocaglamide hydroxamates and related compounds as eukaryotic translation inhibitors: synthetic and biological studies. J Med Chem55:558-62 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Eukaryotic initiation factor 4A-I |
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Name: | Eukaryotic initiation factor 4A-I |
Synonyms: | ATP-dependent RNA helicase eIF4A-1 | DDX2A | EIF4A | EIF4A1 | IF4A1_HUMAN | eIF-4A-I | eIF4A-I |
Type: | PROTEIN |
Mol. Mass.: | 46146.87 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_864983 |
Residue: | 406 |
Sequence: | MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ
RAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVV
MALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFV
LDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE
LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS
AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI
GRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
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BDBM50388144 |
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n/a |
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Name | BDBM50388144 |
Synonyms: | CHEMBL2058177 |
Type | Small organic molecule |
Emp. Form. | C28H29NO8 |
Mol. Mass. | 507.5318 |
SMILES | CONC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(OC)cc3OC |r| |
Structure |
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