| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN |
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| Ligand | BDBM50388723 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_829771 (CHEMBL2061290) |
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| IC50 | 8870±n/a nM |
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| Citation |  Mak, LH; Knott, J; Scott, KA; Scott, C; Whyte, GF; Ye, Y; Mann, DJ; Ces, O; Stivers, J; Woscholski, R Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases. Bioorg Med Chem20:4371-6 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN |
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| Name: | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN |
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| Synonyms: | MMAC1 | Mutated in multiple advanced cancers 1 | PTEN | PTEN_HUMAN | Phosphatase and tensin homolog | TEP1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47164.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_829771 |
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| Residue: | 403 |
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| Sequence: | MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK
HKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVA
AIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY
LLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMY
FEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEI
DSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEAS
SSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV
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| BDBM50388723 |
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| n/a |
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| Name | BDBM50388723 |
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| Synonyms: | CHEMBL2057662 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H11O5Sb |
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| Mol. Mass. | 320.94 |
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| SMILES | OC(=O)CCc1cccc(c1)[Sb](O)(O)=O |
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| Structure | 
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