| Reaction Details |
|---|
 | Report a problem with these data |
| Target | M-phase inducer phosphatase 1 |
|---|
| Ligand | BDBM26613 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_829778 (CHEMBL2061297) |
|---|
| Ki | 72±n/a nM |
|---|
| Citation |  Mak, LH; Knott, J; Scott, KA; Scott, C; Whyte, GF; Ye, Y; Mann, DJ; Ces, O; Stivers, J; Woscholski, R Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases. Bioorg Med Chem20:4371-6 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| M-phase inducer phosphatase 1 |
|---|
| Name: | M-phase inducer phosphatase 1 |
|---|
| Synonyms: | CDC25A | Dual specificity phosphatase (Cdc25A) | Dual specificity phosphatase Cdc25A | M-phase inducer phosphatase 1 | MPIP1_HUMAN | phosphatase Cdc25 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 59090.18 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P30304 |
|---|
| Residue: | 524 |
|---|
| Sequence: | MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAGGLSPVTNLTVTMDQLQGLGSDYE
QPLEVKNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPMRRIHSLPQKLLGCSPALK
RSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCLHSHGLQEGKDLFTQRQNSAP
ARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASL
WTAPLVMRTTNLDNRCKLFDSPSLCSSSTRSVLKRPERSQEESPPGSTKRRKSMSGASPK
ESTNPEKAHETLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYI
SPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPT
DGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSY
CEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEKSKREMYSRLKKL
|
|
|
|---|
| BDBM26613 |
|---|
| n/a |
|---|
| Name | BDBM26613 |
|---|
| Synonyms: | (2E)-3-{3-[dihydroxy(oxo)--stibanyl]phenyl}prop-2-enoic acid | Compound 13778 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C9H9O5Sb |
|---|
| Mol. Mass. | 318.92 |
|---|
| SMILES | OC(=O)\C=C\c1cccc(c1)[Sb](O)(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
