Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetN-acylethanolamine-hydrolyzing acid amidase
LigandBDBM50389015
Substrate/Competitorn/a
Meas. Tech.ChEMBL_832910 (CHEMBL2066781)
IC50 15000±n/a nM
Citation Duranti, A; Tontini, A; Antonietti, F; Vacondio, F; Fioni, A; Silva, C; Lodola, A; Rivara, S; Solorzano, C; Piomelli, D; Tarzia, G; Mor, M N-(2-oxo-3-oxetanyl)carbamic acid esters as N-acylethanolamine acid amidase inhibitors: synthesis and structure-activity and structure-property relationships. J Med Chem55:4824-36 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
N-acylethanolamine-hydrolyzing acid amidase
Name:N-acylethanolamine-hydrolyzing acid amidase
Synonyms:ASAH-like protein | Asahl | N-acylethanolamine acid amidase (NAAA) | N-acylethanolamine-hydrolyzing acid amidase | N-acylethanolamine-hydrolyzing acid amidase (NAAA) | N-acylethanolamine-hydrolyzing acid amidase subunit alpha | N-acylethanolamine-hydrolyzing acid amidase subunit beta | N-acylsphingosine amidohydrolase-like | NAAA_RAT | Naaa
Type:Enzyme
Mol. Mass.:40306.53
Organism:Rattus norvegicus (Rat)
Description:Q5KTC7
Residue:362
Sequence:
MGTPAIRAACHGAHLALALLLLLSLSDPWLWATAPGTPPLFNVSLDAAPELRWLPMLQHY
DPDFVRAAVAQVIGDRVPQWILEMIGEIVQKVESFLPQPFTSEIRGICDYLNLSLAEGVL
VNLAYEASAFCTSIVAQDSQGRIYHGRNLDYPFGNALRKLTADVQFVKNGQIVFTATTFV
GYVGLWTGQSPHKFTISGDERDKGWWWENMIAALSLGHSPISWLIRKTLTESEDFEAAVY
TLAKTPLIADVYYIVGGTSPQEGVVITRDRGGPADIWPLDPLNGAWFRVETNYDHWEPVP
KRDDRRTPAIKALNATGQAHLSLETLFQVLSVFPVYNNYTIYTTVMSAAEPDKYMTMIRN
PS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50389015
n/a
NameBDBM50389015
Synonyms:CHEMBL2064172 | US9321743, URB784
TypeSmall organic molecule
Emp. Form.C11H12N2O3
Mol. Mass.220.2246
SMILESO=C(NCc1ccccc1)N[C@H]1COC1=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: