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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50389527 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_832416 (CHEMBL2067140) | ||
| IC50 | 70±n/a nM | ||
| Citation |  Takeda, K; Terauchi, T; Hashizume, M; Shin, K; Ino, M; Shibata, H; Yonaga, M Design, synthesis, and structure-activity relationships of a series of 2-Ar-8-methyl-5-alkylaminoquinolines as novel CRF1 receptor antagonists. Bioorg Med Chem Lett22:5372-8 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50389527 | |||
| n/a | |||
| Name | BDBM50389527 | ||
| Synonyms: | CHEMBL2063369 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H36N2O3 | ||
| Mol. Mass. | 436.5863 | ||
| SMILES | CCCN(CCC)c1ccc(C)c2nc(c(C)cc12)-c1c(OC)cc(COC)cc1OC |(41.21,8.74,;41.21,7.19,;39.88,6.41,;39.89,4.87,;41.22,4.11,;42.55,4.88,;43.89,4.12,;38.56,4.1,;37.22,4.86,;35.89,4.09,;35.89,2.55,;34.56,1.78,;37.22,1.78,;37.22,.24,;38.55,-.53,;39.89,.24,;41.23,-.52,;39.89,1.78,;38.56,2.55,;38.56,-2.07,;37.22,-2.84,;35.89,-2.07,;34.55,-2.84,;37.22,-4.38,;38.55,-5.15,;38.56,-6.69,;37.22,-7.46,;35.89,-6.69,;39.89,-4.37,;39.89,-2.83,;41.22,-2.06,;42.55,-2.83,)| | ||
| Structure | 
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