Ki Summary

Reaction Details

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Target

Melanocortin receptor 3

Ligand

BDBM50389770

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_834298 (CHEMBL2073118)

45±n/a nM

Citation

Conde-Frieboes, K; Thøgersen, H; Lau, JF; Sensfuss, U; Hansen, TK; Christensen, L; Spetzler, J; Olsen, HB; Nilsson, C; Raun, K; Dahl, K; Hansen, BS; Wulff, BS Identification and in vivo and in vitro characterization of long acting and melanocortin 4 receptor (MC4-R) selectivea-melanocyte-stimulating hormone (a-MSH) analogues. J Med Chem55:1969-77 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 3

Name:

Melanocortin receptor 3

Synonyms:

MC3-R | MC3R | MC3R_HUMAN | Melanocortin MC3 | Melanocortin receptor (M3 and M4)

Type:

Enzyme

Mol. Mass.:

36044.86

Organism:

Homo sapiens (Human)

Description:

P41968

Residue:

323

Sequence:

MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVI
LAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIF
DSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFI
VYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKG
AVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYA
FRSLELRNTFREILCGCNGMNLG

BDBM50389770

n/a

Name

BDBM50389770

Synonyms:

CHEMBL2070242

Type

Small organic molecule

Emp. Form.

C69H99N21O18

Mol. Mass.

1510.6543

SMILES

CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(C)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O)C(N)=O |r,wU:33.36,24.30,47.47,97.106,86.89,75.78,57.110,wD:14.21,8.10,4.4,61.62,99.103,(4.15,-11.82,;4.94,-10.5,;4.19,-9.15,;4.99,-7.83,;4.23,-6.48,;2.7,-6.46,;1.96,-5.12,;2.74,-3.8,;.41,-5.09,;-.38,-6.41,;-1.92,-6.38,;-.34,-3.74,;.46,-2.42,;2,-2.45,;-.29,-1.08,;-1.83,-1.06,;-2.62,-2.37,;-2.02,-3.79,;-3.18,-4.8,;-4.5,-4.01,;-4.16,-2.52,;.5,.24,;-.25,1.59,;-1.79,1.61,;.54,2.9,;2.08,2.88,;2.87,4.2,;4.41,4.17,;5.16,2.83,;5.2,5.49,;-.21,4.25,;.58,5.57,;2.12,5.55,;-.16,6.91,;.63,8.24,;2.16,8.22,;-1.7,6.94,;-2.45,8.29,;-1.66,9.61,;-3.99,8.32,;-4.74,9.67,;-3.94,10.99,;-4.69,12.33,;-2.4,10.95,;5.03,-5.17,;4.28,-3.82,;6.57,-5.19,;7.36,-3.88,;6.78,-2.45,;7.83,-.82,;7.81,7.48,;6.72,8.58,;29.78,7.54,;29.75,2.34,;28.41,1.59,;28.38,.05,;27.04,-.7,;27.02,-2.24,;25.67,-2.98,;24.35,-2.19,;24.37,-.66,;23.01,-2.95,;22.98,-4.49,;24.3,-5.27,;25.72,-4.67,;26.73,-5.83,;25.94,-7.15,;26.4,-8.62,;25.35,-9.75,;23.85,-9.41,;23.4,-7.94,;24.44,-6.81,;21.68,-2.16,;20.34,-2.91,;20.32,-4.45,;19.02,-2.12,;19.04,-.58,;20.38,.17,;20.41,1.71,;21.75,2.46,;21.77,3.99,;20.45,4.78,;23.12,4.75,;17.68,-2.87,;16.35,-2.09,;16.38,-.54,;15.01,-2.83,;14.99,-4.37,;16.31,-5.16,;17.65,-4.41,;18.97,-5.2,;18.95,-6.73,;17.61,-7.48,;16.29,-6.7,;13.69,-2.04,;12.35,-2.79,;12.32,-4.33,;11.03,-2,;11.13,-.45,;9.49,-.1,;8.81,1.43,;8.64,-1.54,;9.75,-2.81,;8.89,-4.09,;9.55,-5.47,;28.34,-3.03,;29.68,-2.28,;28.31,-4.56,)|

Structure