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TargetGhrelin receptor
LigandBDBM50390071
Substrate/Competitorn/a
Meas. Tech.ChEMBL_834030
IC50 200±n/a nM
Citation Kers ICsjernyik GMacsari INylöf MSandberg LSkogholm KBueters TEriksson ABOerther SLund PEVenyike ENyström JEBesidski Y Structure and activity relationship in the (S)-N-chroman-3-ylcarboxamide series of voltage-gated sodium channel blockers. Bioorg Med Chem Lett 22:5618-24 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ghrelin receptor
Name:Ghrelin receptor
Synonyms:GH-releasing peptide receptor | GHRP | GHS-R | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor 1a (GHS-R1a)
Type:Receptor
Mol. Mass.:41334.57
Organism:Homo sapiens (Human)
Description:Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
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BDBM50390071
n/a
NameBDBM50390071
Synonyms:CHEMBL2069411
TypeSmall organic molecule
Emp. Form.C23H20F3N3O4
Mol. Mass.459.4178
SMILESOCc1ccc(cn1)-c1cccc2OC[C@H](Cc12)NC(=O)c1ccc(OCC(F)(F)F)nc1 |r|
Structure
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