| Reaction Details |
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 | Report a problem with these data |
| Target | Oxysterols receptor LXR-beta |
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| Ligand | BDBM50390737 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_835704 (CHEMBL2071815) |
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| IC50 | 3800±n/a nM |
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| Citation |  Jiao, X; Kopecky, DJ; Fisher, B; Piper, DE; Labelle, M; McKendry, S; Harrison, M; Jones, S; Jaen, J; Shiau, AK; Escaron, P; Danao, J; Chai, A; Coward, P; Kayser, F Discovery and optimization of a series of liver X receptor antagonists. Bioorg Med Chem Lett22:5966-70 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Oxysterols receptor LXR-beta |
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| Name: | Oxysterols receptor LXR-beta |
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| Synonyms: | LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 50978.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P55055 |
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| Residue: | 460 |
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| Sequence: | MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW
VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA
RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQ
SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKR
SFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQI
ALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMR
RLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM
LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
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| BDBM50390737 |
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| n/a |
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| Name | BDBM50390737 |
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| Synonyms: | CHEMBL2070360 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23F3N2O3S |
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| Mol. Mass. | 488.522 |
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| SMILES | CC(C)CN(c1ccc(cc1)C(O)(C#Cc1ccccn1)C(F)(F)F)S(=O)(=O)c1ccccc1 |
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| Structure | 
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