| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/bile acid cotransporter |
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| Ligand | BDBM31768 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_838517 (CHEMBL2078145) |
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| IC50 | 264000±n/a nM |
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| Citation |  Kim, RB; Leake, B; Cvetkovic, M; Roden, MM; Nadeau, J; Walubo, A; Wilkinson, GR Modulation by drugs of human hepatic sodium-dependent bile acid transporter (sodium taurocholate cotransporting polypeptide) activity. J Pharmacol Exp Ther291:1204-9 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/bile acid cotransporter |
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| Name: | Sodium/bile acid cotransporter |
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| Synonyms: | Bile acid transporter | NTCP | NTCP_HUMAN | SLC10A1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 38131.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_838517 |
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| Residue: | 349 |
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| Sequence: | MEAHNASAPFNFTLPPNFGKRPTDLALSVILVFMLFFIMLSLGCTMEFSKIKAHLWKPKG
LAIALVAQYGIMPLTAFVLGKVFRLKNIEALAILVCGCSPGGNLSNVFSLAMKGDMNLSI
VMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIVISLVLVLIPCTIGIVLKSKR
PQYMRYVIKGGMIIILLCSVAVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLLGYVL
SALFCLNGRCRRTVSMETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLL
IAIFWCYEKFKTPKDKTKMIYTAATTEETIPGALGNGTYKGEDCSPCTA
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| BDBM31768 |
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| n/a |
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| Name | BDBM31768 |
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| Synonyms: | CHEMBL295698 | Ketoconazole | Nizoral | Panfungol |
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| Type | Small organic molecule |
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| Emp. Form. | C26H28Cl2N4O4 |
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| Mol. Mass. | 531.431 |
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| SMILES | CC(=O)N1CCN(CC1)c1ccc(OC[C@@H]2CO[C@](Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1 |r| |
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| Structure | 
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