Ki Summary

Reaction Details

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Target

Solute carrier family 22 member 8

Ligand

BDBM20688

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_835954 (CHEMBL2077092)

IC50

13700±n/a nM

Citation

Khamdang, S; Takeda, M; Shimoda, M; Noshiro, R; Narikawa, S; Huang, XL; Enomoto, A; Piyachaturawat, P; Endou, H Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine. J Pharmacol Sci94:197-202 (2004) [PubMed]

More Info.:

Get all data from this article, Assay Method

Solute carrier family 22 member 8

Name:

Solute carrier family 22 member 8

Synonyms:

OAT3 | Organic anion transporter 3 | S22A8_HUMAN | SLC22A8 | hOAT3

Type:

PROTEIN

Mol. Mass.:

59870.13

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1486920

Residue:

542

Sequence:

MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPW
VLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNK
LKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFR
FLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQL
TVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLN
LQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQI
IFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKG
CLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGI
TALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLG
SS

BDBM20688

n/a

Name

BDBM20688

Synonyms:

(3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid | CHEMBL1144 | Pravastatin

Type

Small organic molecule

Emp. Form.

C23H36O7

Mol. Mass.

424.5277

SMILES

[H][C@]12[C@H](C[C@H](O)C=C1C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC(O)=O)OC(=O)[C@@H](C)CC |r,c:6,9|

Structure