| Reaction Details |
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 | Report a problem with these data |
| Target | Exopolyphosphatase PRUNE1 |
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| Ligand | BDBM23620 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_840281 (CHEMBL2091189) |
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| IC50 | 780±n/a nM |
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| Citation |  Virgilio, A; Spano, D; Esposito, V; Di Dato, V; Citarella, G; Marino, N; Maffia, V; De Martino, D; De Antonellis, P; Galeone, A; Zollo, M Novel pyrimidopyrimidine derivatives for inhibition of cellular proliferation and motility induced by h-prune in breast cancer. Eur J Med Chem57:41-50 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Exopolyphosphatase PRUNE1 |
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| Name: | Exopolyphosphatase PRUNE1 |
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| Synonyms: | DRES-17 | DRES17 | Drosophila-related expressed sequence 17 | HTcD37 | PRUN1_HUMAN | PRUNE | PRUNE1 | Protein prune homolog | hPrune |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50187.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_840282 |
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| Residue: | 453 |
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| Sequence: | MEDYLQGCRAALQESRPLHVVLGNEACDLDSTVSALALAFYLAKTTEAEEVFVPVLNIKR
SELPLRGDIVFFLQKVHIPESILIFRDEIDLHALYQAGQLTLILVDHHILSKSDTALEEA
VAEVLDHRPIEPKHCPPCHVSVELVGSCATLVTERILQGAPEILDRQTAALLHGTIILDC
VNMDLKIGKATPKDSKYVEKLEALFPDLPKRNDIFDSLQKAKFDVSGLTTEQMLRKDQKT
IYRQGVKVAISAIYMDLEAFLQRSNLLADLHAFCQAHSYDVLVAMTIFFNTHNEPVRQLA
IFCPHVALQTTICEVLERSHSPPLKLTPASSTHPNLHAYLQGNTQVSRKKLLPLLQEALS
AYFDSMKIPSGQPETADVSREQVDKELDRASNSLISGLSQDEEDPPLPPTPMNSLVDECP
LDQGLPKLSAEAVFEKCSQISLSQSTTASLSKK
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| BDBM23620 |
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| n/a |
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| Name | BDBM23620 |
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| Synonyms: | 2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin-1-yl)pyrimido[5,4-d][1,3]diazin-2-yl}(2-hydroxyethyl)amino)ethan-1-ol | CHEMBL932 | Dipyridamine | Dipyridamole | Dipyudamine | MLS000028420 | Persantine | SMR000058382 | cid_3108 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H40N8O4 |
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| Mol. Mass. | 504.6256 |
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| SMILES | OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO |
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| Structure | 
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