Reaction Details |
| Report a problem with these data |
Target | NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
---|
Ligand | BDBM50216689 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_851438 (CHEMBL2156444) |
---|
IC50 | 91000±n/a nM |
---|
Citation | Suzuki, T; Khan, MN; Sawada, H; Imai, E; Itoh, Y; Yamatsuta, K; Tokuda, N; Takeuchi, J; Seko, T; Nakagawa, H; Miyata, N Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors. J Med Chem55:5760-73 (2012) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
---|
Name: | NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
Synonyms: | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3 |
Type: | Protein |
Mol. Mass.: | 43582.69 |
Organism: | Homo sapiens (Human) |
Description: | Q9NTG7 |
Residue: | 399 |
Sequence: | MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEP
LDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDK
GKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIF
ELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIP
ASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQ
RFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDV
AQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
|
|
|
BDBM50216689 |
---|
n/a |
---|
Name | BDBM50216689 |
Synonyms: | 2-cyano-3-(5-(2,5-dichlorophenyl)furan-2-yl)-N-(quinolin-5-yl)acrylamide | CHEMBL224864 |
Type | Small organic molecule |
Emp. Form. | C23H13Cl2N3O2 |
Mol. Mass. | 434.274 |
SMILES | Clc1ccc(Cl)c(c1)-c1ccc(\C=C(/C#N)C(=O)Nc2cccc3ncccc23)o1 |
Structure |
|