| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 7 |
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| Ligand | BDBM50392432 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_851892 (CHEMBL2156668) |
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| EC50 | >10000±n/a nM |
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| Citation |  Manka, JT; Vinson, PN; Gregory, KJ; Zhou, Y; Williams, R; Gogi, K; Days, E; Jadhav, S; Herman, EJ; Lavreysen, H; Mackie, C; Bartolomé, JM; Macdonald, GJ; Steckler, T; Daniels, JS; Weaver, CD; Niswender, CM; Jones, CK; Conn, PJ; Lindsley, CW; Stauffer, SR Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover. Bioorg Med Chem Lett22:6481-5 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 7 |
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| Name: | Metabotropic glutamate receptor 7 |
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| Synonyms: | GPRC1G | GRM7 | GRM7 protein | GRM7_HUMAN | MGLUR7 | Metabotropic glutamate receptor 7 | metabotropic glutamate 7 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 102262.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q14831 |
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| Residue: | 915 |
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| Sequence: | MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAK
GPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSL
TFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA
STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQ
ISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAK
RADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR
NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAH
ALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIF
QYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTP
CCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAML
GIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRV
FLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIW
FGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGV
PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGML
YMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNS
PAAKKKYVSYNNLVI
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| BDBM50392432 |
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| n/a |
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| Name | BDBM50392432 |
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| Synonyms: | CHEMBL2151817 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H23FN2O2 |
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| Mol. Mass. | 330.3965 |
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| SMILES | C[C@@H](NC(=O)c1ccc(OCc2cccc(F)c2)nc1)C(C)(C)C |r| |
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| Structure | 
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