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TargetDNA topoisomerase 4 subunit B (parE)
LigandBDBM50393079
Substrate/Competitorn/a
Meas. Tech.ChEMBL_853607
Ki 12±n/a nM
Citation Abdel-Magid AF Combatting Drug-Resistant Bacteria with Gyrase and Topoisomerase IV Inhibitors: Patent Highlight. ACS Med Chem Lett 3:783-784 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
DNA topoisomerase 4 subunit B (parE)
Name:DNA topoisomerase 4 subunit B (parE)
Synonyms:DNA topoisomerase 4 subunit B | Topoisomerase IV subunit B | grlB
Type:Enzyme
Mol. Mass.:74365.92
Organism:Staphylococcus aureus
Description:Q2FYS5
Residue:663
Sequence:
MNKQNNYSDDSIQVLEGLEAVRKRPGMYIGSTDKRGLHHLVYEIVDNSVDEVLNGYGNEI
DVTINKDGSISIEDNGRGMPTGIHKSGKPTVEVIFTVLHAGGKFGQGGYKTSGGLHGVGA
SVVNALSEWLEVEIHRDGNIYHQSFKNGGSPSSGLVKKGKTKKTGTKVTFKPDDTIFKAS
TSFNFDVLSERLQESAFLLKNLKITLNDLRSGKERQEHYHYEEGIKEFVSYVNEGKEVLH
DVATFSGEANGIEVDVAFQYNDQYSESILSFVNNVRTKDGGTHEVGFKTAMTRVFNDYAR
RINELKTKDKNLDGNDIREGLTAVVSVRIPEELLQFEGQTKSKLGTSEARSAVDSVVADK
LPFYLEEKGQLSKSLVKKAIKAQQAREAARKAREDARSGKKNKRKDTLLSGKLTPAQSKN
TEKNELYLVEGDSAGGSAKLGRDRKFQAILPLRGKVINTEKARLEDIFKNEEINTIIHTI
GAGVGTDFKIEDSNYNRVIIMTDADTDGAHIQVLLLTFFFKYMKPLVQAGRVFIALPPLY
KLEKGKGKTKRVEYAWTDEELNKLQKELGKGFTLQRYKGLGEMNPEQLWETTMNPETRTL
IRVQVEDEVRSSKRVTTLMGDKVQPRREWIEKHVEFGMQEDQSILDNSEVQVLENDQFDE
EEI
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  Blast E-value cutoff:
BDBM50393079
n/a
NameBDBM50393079
Synonyms:CHEMBL2152855 | US9040542, 23
TypeSmall organic molecule
Emp. Form.C21H25FN6O3
Mol. Mass.428.46
SMILESCCNC(=O)Nc1nc2cc(c(F)c([C@H]3CCCO3)c2[nH]1)-c1cnc(nc1)C(C)(C)O |r|
Structure
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