| Reaction Details |
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 | Report a problem with these data |
| Target | Microtubule-associated protein tau |
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| Ligand | BDBM50393081 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_853608 (CHEMBL2154063) |
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| EC50 | 169±n/a nM |
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| Citation |  Rotella, DP Novel compounds for the treatment of neurodegenerative diseases: patent highlight. ACS Med Chem Lett3:788-788 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Microtubule-associated protein tau |
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| Name: | Microtubule-associated protein tau |
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| Synonyms: | MAPT | MAPTL | MTBT1 | Microtubule-associated protein tau | Neurofibrillary tangle protein | PHF-tau | Paired helical filament-tau | TAU | TAU_HUMAN | Tau Protein |
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| Type: | Protein |
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| Mol. Mass.: | 78928.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10636 |
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| Residue: | 758 |
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| Sequence: | MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPG
SETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAG
HVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEG
GRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPA
QDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLE
FTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPA
AAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSS
DPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQK
GQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREP
KKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLD
LSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEK
LDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDT
SPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
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| BDBM50393081 |
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| n/a |
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| Name | BDBM50393081 |
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| Synonyms: | CHEMBL2152857 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H18ClN3O |
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| Mol. Mass. | 399.872 |
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| SMILES | Clc1ccc2[nH]cc(CCNC(=O)c3cccc(c3)-c3ccccc3C#N)c2c1 |
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| Structure | 
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