| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-1D adrenergic receptor |
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| Ligand | BDBM50026917 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_852796 (CHEMBL2156103) |
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| Kd | 3.02±n/a nM |
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| Citation |  Romeiro, LA; da Silva Ferreira, M; da Silva, LL; Castro, HC; Miranda, AL; Silva, CL; Noël, F; Nascimento, JB; Araújo, CV; Tibiriçá, E; Barreiro, EJ; Fraga, CA Discovery of LASSBio-772, a 1,3-benzodioxole N-phenylpiperazine derivative with potent alpha 1A/D-adrenergic receptor blocking properties. Eur J Med Chem46:3000-12 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-1D adrenergic receptor |
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| Name: | Alpha-1D adrenergic receptor |
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| Synonyms: | ADA1D_RAT | Adra1a | Adra1d | Alpha adrenergic receptor 1A and 1D | Alpha-1D adrenergic receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 |
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| Type: | Protein |
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| Mol. Mass.: | 59375.97 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P23944 |
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| Residue: | 561 |
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| Sequence: | MTFRDILSVTFEGPRSSSSTGGSGAGGGAGTVGPEGGAVGGVPGATGGGAVVGTGSGEDN
QSSTGEPGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRH
LQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILS
LCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFC
GITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRI
HCRGAATSAKGYPGTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFF
VLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRR
RLWAVYGHHWRASTGDARSDCAPSPRIAPPGAPLALTAHPGAGSADTPETQDSVSSSRKP
ASALREWRLLGPLQRPTTQLRAKVSSLSHKIRSGARRAETACALRSEVEAVSLNVPQDGA
EAVICQAYEPGDYSNLRETDI
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| BDBM50026917 |
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| n/a |
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| Name | BDBM50026917 |
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| Synonyms: | 8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-azaspiro[4.5]decane-7,9-dione | 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione | 8-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-8-aza-spiro[4.5]decane-7,9-dione | 8-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-8-aza-spiro[4.5]decane-7,9-dione(BMY-7378) | BMY 7378 | BMY-7378 | CHEMBL1256934 | CHEMBL13647 | CHEMBL543741 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H31N3O3 |
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| Mol. Mass. | 385.4998 |
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| SMILES | COc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 |
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| Structure | 
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