| Reaction Details |
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 | Report a problem with these data |
| Target | Smoothened homolog |
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| Ligand | BDBM50394395 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_854592 (CHEMBL2161253) |
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| IC50 | 0.2±n/a nM |
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| Citation |  Cheng, D; Han, D; Gao, W; Jing, Q; Jiang, J; Wan, Y; Englund, NP; Tuntland, T; Wu, X; Pan, S Design, synthesis, and structure-activity-relationship of phenyl imidazoles as potent Smoothened antagonists. Bioorg Med Chem Lett22:6573-6 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Smoothened homolog |
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| Name: | Smoothened homolog |
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| Synonyms: | SMO_MOUSE | Smo | Smoh |
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| Type: | PROTEIN |
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| Mol. Mass.: | 87472.73 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1510377 |
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| Residue: | 793 |
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| Sequence: | MAAGRPVRGPELAPRRLLQLLLLVLLGGPGRGAALSGNVTGPGPHSASGSSRRDVPVTSP
PPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHGKLVLWSGLRNAP
RCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPE
GCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAA
FGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR
ADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGK
TSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGG
YFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFN
QAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWV
WTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSH
DGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEQANMWL
VEAEISPELEKRLGRKKKRRKRKKEVCPLRPAPELHHSAPVPATSAVPRLPQLPRQKCLV
AANAWGTGESCRQGAWTLVSNPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTN
LMEAEILDADSDF
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| BDBM50394395 |
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| n/a |
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| Name | BDBM50394395 |
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| Synonyms: | CHEMBL2160078 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H26N4O2 |
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| Mol. Mass. | 438.5209 |
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| SMILES | Cc1ccc(NC(=O)c2ccc(cc2)N2CCOCC2)cc1-c1nc(c[nH]1)-c1ccccc1 |
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| Structure | 
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