| Reaction Details |
|---|
 | Report a problem with these data |
| Target | ATP-citrate synthase |
|---|
| Ligand | BDBM50394671 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_857792 (CHEMBL2169035) |
|---|
| Ki | 340±n/a nM |
|---|
| Citation |  Abramson, HN The lipogenesis pathway as a cancer target. J Med Chem54:5615-38 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| ATP-citrate synthase |
|---|
| Name: | ATP-citrate synthase |
|---|
| Synonyms: | ACLY | ACLY_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 120848.43 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_455196 |
|---|
| Residue: | 1101 |
|---|
| Sequence: | MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQNLVVKPD
QLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHSQAEEFY
VCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNPEDIKKHLLVHAPEDKKEI
LASFISGLFNFYEDLYFTYLEINPLVVTKDGVYVLDLAAKVDATADYICKVKWGDIEFPP
PFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNE
LANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRA
IRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALG
HRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVP
SPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQK
FYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEG
IPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYV
SRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIG
GTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALK
EAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASF
MTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADH
GPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFV
NKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPN
LILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLK
QGLYRHPWDDISYVLPEHMSM
|
|
|
|---|
| BDBM50394671 |
|---|
| n/a |
|---|
| Name | BDBM50394671 |
|---|
| Synonyms: | CHEMBL2165260 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H32ClNO6 |
|---|
| Mol. Mass. | 465.967 |
|---|
| SMILES | Cc1cn(cc1C)-c1cc(Cl)ccc1CCCCCC[C@H](O)C[C@@](O)(CC(O)=O)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
