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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Lanosterol synthase | ||
| Ligand | BDBM50394832 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_860118 (CHEMBL2168444) | ||
| IC50 | 28.7±n/a nM | ||
| Citation |  Staedler, D; Chapuis-Bernasconi, C; Dehmlow, H; Fischer, H; Juillerat-Jeanneret, L; Aebi, JD Cytotoxic effects of combination of oxidosqualene cyclase inhibitors with atorvastatin in human cancer cells. J Med Chem55:4990-5002 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Lanosterol synthase | |||
| Name: | Lanosterol synthase | ||
| Synonyms: | 2,3-epoxysqualene--lanosterol cyclase | LSS | LSS_HUMAN | OSC | Oxidosqualene--lanosterol cyclase | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 83309.32 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_11231 | ||
| Residue: | 732 | ||
| Sequence: |
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| BDBM50394832 | |||
| n/a | |||
| Name | BDBM50394832 | ||
| Synonyms: | CHEMBL2164238 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H31ClN2O4 | ||
| Mol. Mass. | 422.946 | ||
| SMILES | CN(CC[C@H]1CC[C@@H](CC1)C(=O)N1CCC(O)CC1)C(=O)Oc1ccc(Cl)cc1 |r,wU:7.10,wD:4.3,(42.05,-39.41,;42.04,-40.95,;40.7,-41.71,;39.38,-40.93,;38.04,-41.69,;36.71,-40.92,;35.36,-41.68,;35.37,-43.22,;36.7,-44,;38.03,-43.23,;34.04,-43.99,;34.03,-45.53,;32.7,-43.21,;31.37,-43.98,;30.05,-43.21,;30.05,-41.67,;28.71,-40.91,;31.37,-40.9,;32.7,-41.67,;43.37,-41.72,;43.36,-43.26,;44.71,-40.96,;46.04,-41.74,;46.02,-43.28,;47.35,-44.05,;48.69,-43.29,;50.02,-44.07,;48.69,-41.74,;47.36,-40.97,)| | ||
| Structure | 
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