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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Lanosterol synthase | ||
| Ligand | BDBM50394833 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_860118 (CHEMBL2168444) | ||
| IC50 | 11.2±n/a nM | ||
| Citation |  Staedler, D; Chapuis-Bernasconi, C; Dehmlow, H; Fischer, H; Juillerat-Jeanneret, L; Aebi, JD Cytotoxic effects of combination of oxidosqualene cyclase inhibitors with atorvastatin in human cancer cells. J Med Chem55:4990-5002 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Lanosterol synthase | |||
| Name: | Lanosterol synthase | ||
| Synonyms: | 2,3-epoxysqualene--lanosterol cyclase | LSS | LSS_HUMAN | OSC | Oxidosqualene--lanosterol cyclase | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 83309.32 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_11231 | ||
| Residue: | 732 | ||
| Sequence: |
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| BDBM50394833 | |||
| n/a | |||
| Name | BDBM50394833 | ||
| Synonyms: | CHEMBL2164237 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H35F3N2O3S | ||
| Mol. Mass. | 464.585 | ||
| SMILES | CN(CCO)CCCCC[C@H]1CC[C@@H](CC1)N(C)S(=O)(=O)c1ccc(cc1)C(F)(F)F |r,wU:10.9,wD:13.16,(5.65,-46.1,;5.65,-47.64,;4.32,-48.41,;2.99,-47.63,;1.65,-48.4,;6.99,-48.41,;8.32,-47.64,;9.65,-48.41,;10.99,-47.64,;12.32,-48.41,;13.66,-47.64,;13.66,-46.1,;14.99,-45.33,;16.32,-46.11,;16.33,-47.64,;14.99,-48.41,;17.65,-45.33,;18.99,-46.1,;17.64,-43.79,;16.1,-43.8,;16.87,-42.45,;18.98,-43.02,;20.32,-43.8,;21.66,-43.03,;21.67,-41.48,;20.32,-40.7,;18.98,-41.48,;23.01,-40.7,;24.34,-41.47,;23,-39.16,;24.33,-39.93,)| | ||
| Structure | 
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