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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Lanosterol synthase | ||
| Ligand | BDBM50394835 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_860118 (CHEMBL2168444) | ||
| IC50 | 7.8±n/a nM | ||
| Citation |  Staedler, D; Chapuis-Bernasconi, C; Dehmlow, H; Fischer, H; Juillerat-Jeanneret, L; Aebi, JD Cytotoxic effects of combination of oxidosqualene cyclase inhibitors with atorvastatin in human cancer cells. J Med Chem55:4990-5002 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Lanosterol synthase | |||
| Name: | Lanosterol synthase | ||
| Synonyms: | 2,3-epoxysqualene--lanosterol cyclase | LSS | LSS_HUMAN | OSC | Oxidosqualene--lanosterol cyclase | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 83309.32 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_11231 | ||
| Residue: | 732 | ||
| Sequence: |
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| BDBM50394835 | |||
| n/a | |||
| Name | BDBM50394835 | ||
| Synonyms: | CHEMBL2164235 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H33ClN2O2 | ||
| Mol. Mass. | 404.973 | ||
| SMILES | CCCN(C)CCCC#C[C@H]1CC[C@@H](CC1)N(C)C(=O)Oc1ccc(Cl)cc1 |r,wU:10.9,wD:13.16,(22.91,-26.91,;24.24,-26.14,;24.24,-24.6,;25.57,-23.83,;25.57,-22.29,;26.9,-24.59,;28.23,-23.82,;29.57,-24.58,;30.9,-23.81,;32.24,-23.03,;33.57,-22.26,;33.57,-20.72,;34.9,-19.94,;36.23,-20.72,;36.23,-22.26,;34.9,-23.02,;37.56,-19.95,;37.57,-18.41,;38.89,-20.73,;38.89,-22.27,;40.23,-19.96,;41.56,-20.74,;41.56,-22.28,;42.89,-23.05,;44.23,-22.29,;45.56,-23.06,;44.23,-20.74,;42.89,-19.97,)| | ||
| Structure | 
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