Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mu-type opioid receptor | ||
| Ligand | BDBM50395098 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_859458 (CHEMBL2167536) | ||
| Ki | 6.5±n/a nM | ||
| Citation |  Majumdar, S; Subrath, J; Le Rouzic, V; Polikar, L; Burgman, M; Nagakura, K; Ocampo, J; Haselton, N; Pasternak, AR; Grinnell, S; Pan, YX; Pasternak, GW Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associatedµ opioid receptor (MOR-1) splice variants. J Med Chem55:6352-62 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mu-type opioid receptor | |||
| Name: | Mu-type opioid receptor | ||
| Synonyms: | M-OR-1 | MOR-1 | Mor | OPIATE Mu | OPRM_MOUSE | Opioid receptors; mu and delta | Oprm | Oprm1 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 44431.62 | ||
| Organism: | MOUSE | ||
| Description: | OPIATE Mu OPRM1 MOUSE::P42866 | ||
| Residue: | 398 | ||
| Sequence: |
| ||
| BDBM50395098 | |||
| n/a | |||
| Name | BDBM50395098 | ||
| Synonyms: | CHEMBL2163532 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H38N2O4 | ||
| Mol. Mass. | 490.6337 | ||
| SMILES | Oc1ccc2C[C@H]3N(CC=C)CC[C@@]45[C@@H](Oc1c24)[C@@H](CC[C@@]35O)NC(=O)C1C2CC3CC(C2)CC1C3 |r,wU:21.26,6.6,18.27,wD:13.19,14.14,TLB:35:34:28.29.30:32,THB:35:29:32:26.34.33,24:26:28.29.30:32,30:29:26:31.32.33,30:31:26:28.29.35,(8.77,-11.54,;9.57,-10.18,;8.79,-8.87,;9.57,-7.54,;11.11,-7.54,;11.85,-6.2,;13.35,-6.2,;13.39,-4.66,;14.17,-3.31,;15.71,-3.29,;16.46,-1.95,;12.6,-5.64,;12.6,-7.54,;13.39,-8.87,;14.14,-10.18,;12.56,-11.1,;11.11,-10.18,;11.85,-8.87,;15.68,-10.19,;16.47,-8.87,;15.71,-7.54,;14.17,-7.54,;14.93,-6.18,;16.43,-11.54,;17.97,-11.56,;18.76,-10.24,;18.72,-12.92,;20.15,-12.88,;18.77,-13.73,;18.3,-15.24,;19.46,-16.21,;20.81,-15.31,;21.3,-13.86,;19.38,-15.21,;18.27,-14.34,;16.73,-15.18,)| | ||
| Structure | 
| ||