Reaction Details |
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Target | 5-hydroxytryptamine receptor 7 |
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Ligand | BDBM50001862 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_859806 (CHEMBL2166090) |
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Ki | 243±n/a nM |
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Citation | Lacivita, E; Patarnello, D; Stroth, N; Caroli, A; Niso, M; Contino, M; De Giorgio, P; Di Pilato, P; Colabufo, NA; Berardi, F; Perrone, R; Svenningsson, P; Hedlund, PB; Leopoldo, M Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo. J Med Chem55:6375-80 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 7 |
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Name: | 5-hydroxytryptamine receptor 7 |
Synonyms: | 5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-Hydroxytryptamine receptor 7 (5-HT7) | 5-hydroxytryptamine receptor 7 | 5-hydroxytryptamine receptor 7 (5-HT-7) | 5HT7R_RAT | Adrenergic Alpha | GPRFO | Htr7 | Serotonin (5-HT) receptor | Serotonin Receptor 7 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 49852.62 |
Organism: | Rattus norvegicus (rat) |
Description: | Rat cloned 5-HT7R. |
Residue: | 448 |
Sequence: | MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPA
PTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSN
YLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS
IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDF
GYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQK
EVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTS
CSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHE
ALKLAERPERSEFVLQNSDHCGKKGHDT
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BDBM50001862 |
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n/a |
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Name | BDBM50001862 |
Synonyms: | (N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl)-piperazine | 1-(2-Methoxy-phenyl)-piperazine | 2-METHOXYPHENYLPIPERAZINE | 4-(2-Methoxy-phenyl)-piperazin-1-ium | CHEMBL9666 | EN300-33366 |
Type | Small organic molecule |
Emp. Form. | C11H16N2O |
Mol. Mass. | 192.2575 |
SMILES | COc1ccccc1N1CCNCC1 |
Structure |
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