| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H1 receptor |
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| Ligand | BDBM50240514 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_858530 (CHEMBL2169534) |
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| IC50 | 1.000±n/a nM |
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| Citation |  Vasudevan, SR; Moore, JB; Schymura, Y; Churchill, GC Shape-based reprofiling of FDA-approved drugs for the H1 histamine receptor. J Med Chem55:7054-60 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H1 receptor |
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| Name: | Histamine H1 receptor |
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| Synonyms: | H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 55808.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay. |
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| Residue: | 487 |
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| Sequence: | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
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| BDBM50240514 |
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| n/a |
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| Name | BDBM50240514 |
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| Synonyms: | (3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethylpropan-1-amine | (Z)-2-Chloro-9-(omega-dimethylaminopropylidene)thioxanthene | (Z)-chlorprothixene | CHEMBL908 | CHLORPROTHIXENE | cis-2-Chloro-9-(3-dimethylaminopropylidene)thioxanthene |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18ClNS |
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| Mol. Mass. | 315.86 |
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| SMILES | CN(C)CC\C=C1\c2ccccc2Sc2ccc(Cl)cc12 |
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| Structure | 
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