| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M4 |
|---|
| Ligand | BDBM50395966 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_858564 (CHEMBL2166009) |
|---|
| IC50 | 140±n/a nM |
|---|
| Citation |  Poslusney, MS; Sevel, C; Utley, TJ; Bridges, TM; Morrison, RD; Kett, NR; Sheffler, DJ; Niswender, CM; Daniels, JS; Conn, PJ; Lindsley, CW; Wood, MR Synthesis and biological characterization of a series of novel diaryl amide M1 antagonists. Bioorg Med Chem Lett22:6923-8 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Muscarinic acetylcholine receptor M4 |
|---|
| Name: | Muscarinic acetylcholine receptor M4 |
|---|
| Synonyms: | ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 53079.31 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173 |
|---|
| Residue: | 479 |
|---|
| Sequence: | MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN
RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV
MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV
PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK
TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS
ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV
PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
|
|
|
|---|
| BDBM50395966 |
|---|
| n/a |
|---|
| Name | BDBM50395966 |
|---|
| Synonyms: | CHEMBL2164905 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H23FN2O |
|---|
| Mol. Mass. | 326.4078 |
|---|
| SMILES | CN1CCN(CC1)C(=O)[C@@](F)(Cc1ccccc1)c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
