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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | NAD-dependent protein deacetylase sirtuin-2 | ||
| Ligand | BDBM50396054 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_861567 (CHEMBL2174508) | ||
| IC50 | 11000±n/a nM | ||
| Citation |  Blum, CA; Ellis, JL; Loh, C; Ng, PY; Perni, RB; Stein, RL SIRT1 modulation as a novel approach to the treatment of diseases of aging. J Med Chem54:417-32 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| NAD-dependent protein deacetylase sirtuin-2 | |||
| Name: | NAD-dependent protein deacetylase sirtuin-2 | ||
| Synonyms: | NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2) | ||
| Type: | Hydrolase | ||
| Mol. Mass.: | 43172.62 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 389 | ||
| Sequence: |
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| BDBM50396054 | |||
| n/a | |||
| Name | BDBM50396054 | ||
| Synonyms: | CHEMBL1537405 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C15H11N3O3S | ||
| Mol. Mass. | 313.331 | ||
| SMILES | Cc1ccc2[nH]c(=O)c(C=C3C(=O)NC(=S)NC3=O)cc2c1 |(7.63,2.39,;6.3,3.16,;6.3,4.7,;4.97,5.47,;3.63,4.7,;2.3,5.47,;.97,4.7,;-.37,5.47,;.97,3.16,;-.37,2.39,;-.37,.85,;-1.7,.08,;-3.04,.85,;-1.7,-1.46,;-.37,-2.23,;-.37,-3.77,;.97,-1.46,;.97,.08,;2.3,.85,;2.3,2.39,;3.63,3.16,;4.97,2.39,)| | ||
| Structure | 
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