| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase SYK |
|---|
| Ligand | BDBM50132437 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_861813 (CHEMBL2173406) |
|---|
| EC50 | >10000±n/a nM |
|---|
| Citation |  Singh, R; Masuda, ES; Payan, DG Discovery and development of spleen tyrosine kinase (SYK) inhibitors. J Med Chem55:3614-43 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase SYK |
|---|
| Name: | Tyrosine-protein kinase SYK |
|---|
| Synonyms: | KSYK_RAT | Syk |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 71541.93 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1348392 |
|---|
| Residue: | 629 |
|---|
| Sequence: | MAGNAVDNANHLTYFFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNRKA
HHYTIERELNGTYAISGGRAHASPADLCHYHSQEPEGLVCLLKKPFNRPPGVQPKTGPFE
DLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGNISRDESEQT
VLIGSKTNGKFLIRARDNNGSFALCLLHEGKVLHYRIDRDKTGKLSIPEGKKFDTLWQLV
EHYSYKPDGLLRVLTVPCQKIGVQMGHPGSSNAHPVTWSPGGIISRIKSYSFPKPGHKKP
PPPQGSRPESTVSFNPYEPTGGAWGPDRGLQREALPMDTEVYESPYADPEEIRPKEVYLD
RKLLTLEDNELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQ
LDNPYIVRMIGICEAESWMLVMEMAAWGPLNKYLQQNRHIKDKNIIELVHQVSMGMKYLE
ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY
FKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPPGCPREMYDLMF
LCWTYDVENRPGFAAVELRLRNYYYDVVN
|
|
|
|---|
| BDBM50132437 |
|---|
| n/a |
|---|
| Name | BDBM50132437 |
|---|
| Synonyms: | 3-((1-(3-hydroxypropyl)-5-methoxy-1H-indol-3-yl)methylene)-2-oxoindoline-5-sulfonamide | 3-[1-[1-(3-Hydroxy-propyl)-5-methoxy-1H-indol-3-yl]-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide | CHEMBL107061 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H21N3O5S |
|---|
| Mol. Mass. | 427.474 |
|---|
| SMILES | COc1ccc2n(CCCO)cc(\C=C3/C(=O)Nc4ccc(cc34)S(N)(=O)=O)c2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
