| Reaction Details |
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 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-7 |
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| Ligand | BDBM50397942 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_872705 (CHEMBL2184685) |
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| Ki | 6300±n/a nM |
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| Citation |  Mazurov, AA; Miao, L; Bhatti, BS; Strachan, JP; Akireddy, S; Murthy, S; Kombo, D; Xiao, YD; Hammond, P; Zhang, J; Hauser, TA; Jordan, KG; Miller, CH; Speake, JD; Gatto, GJ; Yohannes, D Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selectivea4ß2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders. J Med Chem55:9181-94 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuronal acetylcholine receptor subunit alpha-7 |
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| Name: | Neuronal acetylcholine receptor subunit alpha-7 |
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| Synonyms: | ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR) |
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| Type: | n/a |
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| Mol. Mass.: | 56448.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | CHRNA7 (NACHRA7) |
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| Residue: | 502 |
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| Sequence: | MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL
QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK
QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL
LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
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| BDBM50397942 |
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| n/a |
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| Name | BDBM50397942 |
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| Synonyms: | CHEMBL2179534 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H13BrN2O2 |
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| Mol. Mass. | 285.137 |
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| SMILES | Brc1ccoc1C(=O)N1CC2CNCC2C1 |
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| Structure | 
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