| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase haspin |
|---|
| Ligand | BDBM50364776 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_874451 (CHEMBL2184774) |
|---|
| IC50 | 34±n/a nM |
|---|
| Citation |  Drygin, D; Haddach, M; Pierre, F; Ryckman, DM Potential use of selective and nonselective Pim kinase inhibitors for cancer therapy. J Med Chem55:8199-208 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase haspin |
|---|
| Name: | Serine/threonine-protein kinase haspin |
|---|
| Synonyms: | GSG2 | Germ cell-specific gene 2 protein | H-haspin | HASPIN | HASP_HUMAN | Haploid germ cell-specific nuclear protein kinase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 88531.28 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1510616 |
|---|
| Residue: | 798 |
|---|
| Sequence: | MAASLPGPGSRLFRTYGAADGRRQRRPGREAAQWFPPQDRRRFFNSSGSSDASIGDPSQS
DDPDDPDDPDFPGSPVRRRRRRPGGRVPKDRPSLTVTPKRWKLRARPSLTVTPRRLGLRA
RPPQKCSTPCGPLRLPPFPSRDSGRLSPDLSVCGQPRDGDELGISASLFSSLASPCPGSP
TPRDSVISIGTSACLVAASAVPSGLHLPEVSLDRASLPCSQEEATGGAKDTRMVHQTRAS
LRSVLFGLMNSGTPEDSEFRADGKNMRESCCKRKLVVGNGPEGPGLSSTGKRRATGQDSC
QERGLQEAVRREHQEASVPKGRIVPRGIDRLERTRSSRKSKHQEATETSLLHSHRFKKGQ
KLGKDSFPTQDLTPLQNVCFWTKTRASFSFHKKKIVTDVSEVCSIYTTATSLSGSLLSEC
SNRPVMNRTSGAPSSWHSSSMYLLSPLNTLSISNKKASDAEKVYGECSQKGPVPFSHCLP
TEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISK
ELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLF
IVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKT
SLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFD
IYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQIKRKIQEFHRT
MLNFSSATDLLCQHSLFK
|
|
|
|---|
| BDBM50364776 |
|---|
| n/a |
|---|
| Name | BDBM50364776 |
|---|
| Synonyms: | CHEMBL1952141 | CHEMBL1952329 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H22F3N5O |
|---|
| Mol. Mass. | 405.4168 |
|---|
| SMILES | CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
