| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-secretase 1 |
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| Ligand | BDBM50398264 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_874707 (CHEMBL2187563) |
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| IC50 | 51±n/a nM |
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| Citation |  Swahn, BM; Kolmodin, K; Karlström, S; von Berg, S; Söderman, P; Holenz, J; Berg, S; Lindström, J; Sundström, M; Turek, D; Kihlström, J; Slivo, C; Andersson, L; Pyring, D; Rotticci, D; Ohberg, L; Kers, A; Bogar, K; von Kieseritzky, F; Bergh, M; Olsson, LL; Janson, J; Eketjäll, S; Georgievska, B; Jeppsson, F; Fälting, J Design and synthesis ofß-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors with in vivo brain reduction ofß-amyloid peptides. J Med Chem55:9346-61 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-secretase 1 |
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| Name: | Beta-secretase 1 |
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| Synonyms: | BACE1_MOUSE | Bace | Bace1 | Beta-secretase 1 | Beta-secretase 1 (BACE1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 55739.56 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P56818 |
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| Residue: | 501 |
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| Sequence: | MAPALHWLLLWVGSGMLPAQGTHLGIRLPLRSGLAGPPLGLRLPRETDEESEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGAGFPLNQTEALASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRHQHDDFADDISLLK
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| BDBM50398264 |
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| n/a |
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| Name | BDBM50398264 |
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| Synonyms: | CHEMBL2177913 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H16F3N5 |
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| Mol. Mass. | 431.4125 |
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| SMILES | NC1=N[C@@](c2cccc(F)c12)(c1cccc(c1)-c1cncnc1)c1ccnc(c1)C(F)F |r,t:1| |
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| Structure | 
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