| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endothelial PAS domain-containing protein 1 |
|---|
| Ligand | BDBM50240865 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_875592 (CHEMBL2184390) |
|---|
| EC50 | 3300±n/a nM |
|---|
| Citation |  McKee, TC; Rabe, D; Bokesch, HR; Grkovic, T; Whitson, EL; Diyabalanage, T; Van Wyk, AW; Marcum, SR; Gardella, RS; Gustafson, KR; Linehan, WM; McMahon, JB; Bottaro, DP Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges. J Nat Prod75:1632-6 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Endothelial PAS domain-containing protein 1 |
|---|
| Name: | Endothelial PAS domain-containing protein 1 |
|---|
| Synonyms: | BHLHE73 | EPAS1 | EPAS1_HUMAN | HIF2A | MOP2 | PASD2 | endothelial PAS domain-containing protein 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 96453.58 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1506501 |
|---|
| Residue: | 870 |
|---|
| Sequence: | MTADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLA
ISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMG
LTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRG
RTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLD
SKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKG
QVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTE
SLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGNQN
FEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATSSSSSCS
TPNSPEDYYTSLDNDLKIEVIEKLFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDF
QLSPICPEERLLAENPQSTPQHCFSAMTNIFQPLAPVAPHSPFLLDKFQQQLESKKTEPE
HRPMSSIFFDAGSKASLPPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWAVGDQRTE
FLGAAPLGPPVSPPHVSTFKTRSAKGFGARGPDVLSPAMVALSNKLKLKRQLEYEEQAFQ
DLSGGDPPGGSTSHLMWKRMKNLRGGSCPLMPDKPLSANVPNDKFTQNPMRGLGHPLRHL
PLPQPPSAISPGENSKSRFPPQCYATQYQDYSLSSAHKVSGMASRLLGPSFESYLLPELT
RYDCEVNVPVLGSSTLLQGGDLLRALDQAT
|
|
|
|---|
| BDBM50240865 |
|---|
| n/a |
|---|
| Name | BDBM50240865 |
|---|
| Synonyms: | (4aS,6aS,12aR,12bS)-10-Hydroxy-4,4,6a,12b-tetramethyl-1,2,3,4,4a,5,6,6a,12a,12b-decahydro-benzo[a]xanthen-9-one | CHEMBL157844 | PUUPEHENONE |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H28O3 |
|---|
| Mol. Mass. | 328.4452 |
|---|
| SMILES | CC1(C)CCC[C@@]2(C)[C@H]1CC[C@]1(C)OC3=CC(=O)C(=O)CC3=C[C@H]21 |r,c:23,t:15| |
|---|
| Structure | 
|
|---|
Search and Browse
