| Reaction Details |
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 | Report a problem with these data |
| Target | Uridine 5'-monophosphate synthase |
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| Ligand | BDBM50398698 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_874989 (CHEMBL2183865) |
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| Ki | 28300±n/a nM |
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| Citation |  Purohit, MK; Poduch, E; Wei, LW; Crandall, IE; To, T; Kain, KC; Pai, EF; Kotra, LP Novel cytidine-based orotidine-5'-monophosphate decarboxylase inhibitors with an unusual twist. J Med Chem55:9988-97 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Uridine 5'-monophosphate synthase |
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| Name: | Uridine 5'-monophosphate synthase |
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| Synonyms: | Orotate phosphoribosyltransferase (HsOPRT) | Orotidine Monophosphate Decarboxylase (ODCase) | UMPS | UMPS_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 52224.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11172 |
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| Residue: | 480 |
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| Sequence: | MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQT
AQNAGISFDTVCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCL
IIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKML
EILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSIKEAPKELSFGARAELPRIHPVA
SKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELIT
LAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLP
LHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQ
LEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV
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| BDBM50398698 |
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| n/a |
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| Name | BDBM50398698 |
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| Synonyms: | CHEMBL2178721 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H12N3O9P |
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| Mol. Mass. | 337.1811 |
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| SMILES | Nc1ccn([C@@H]2O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]2O)c(=O)[n+]1[O-] |r| |
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| Structure | 
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