| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity protein kinase CLK4 |
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| Ligand | BDBM50347750 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_875228 (CHEMBL2186711) |
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| Kd | 70±n/a nM |
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| Citation |  Tahtouh, T; Elkins, JM; Filippakopoulos, P; Soundararajan, M; Burgy, G; Durieu, E; Cochet, C; Schmid, RS; Lo, DC; Delhommel, F; Oberholzer, AE; Pearl, LH; Carreaux, F; Bazureau, JP; Knapp, S; Meijer, L Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. J Med Chem55:9312-30 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity protein kinase CLK4 |
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| Name: | Dual specificity protein kinase CLK4 |
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| Synonyms: | CDC-like kinase 4 | CLK4 | CLK4_HUMAN | Dual specificity protein kinase CLK1/CLK4 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 57522.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_10190706 |
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| Residue: | 481 |
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| Sequence: | MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEAR
SLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRH
CSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHG
MDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFE
LLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYV
VKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDV
WSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEH
SSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKK
K
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| BDBM50347750 |
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| n/a |
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| Name | BDBM50347750 |
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| Synonyms: | CHEMBL1802358 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13N3O3 |
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| Mol. Mass. | 307.3034 |
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| SMILES | O=C1NC(Nc2ccccc2)=NC1=Cc1ccc2OCOc2c1 |w:13.15,c:11| |
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| Structure | 
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