Reaction Details |
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Target | Dual specificity protein kinase CLK2 |
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Ligand | BDBM50292406 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_875431 (CHEMBL2182298) |
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IC50 | 2100±n/a nM |
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Citation | Tahtouh, T; Elkins, JM; Filippakopoulos, P; Soundararajan, M; Burgy, G; Durieu, E; Cochet, C; Schmid, RS; Lo, DC; Delhommel, F; Oberholzer, AE; Pearl, LH; Carreaux, F; Bazureau, JP; Knapp, S; Meijer, L Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. J Med Chem55:9312-30 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dual specificity protein kinase CLK2 |
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Name: | Dual specificity protein kinase CLK2 |
Synonyms: | CDC-like kinase 2 | CLK2_MOUSE | Clk2 |
Type: | PROTEIN |
Mol. Mass.: | 60021.57 |
Organism: | Mus musculus |
Description: | ChEMBL_1502246 |
Residue: | 499 |
Sequence: | MPHPRRYHSSERGSRGSYHEHYQSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYD
DHSSDRRLYDRRYCGSYRRNDYSRDRGEAYYDTDFRQSYEYHRENSSYRSQRSSRRKHRR
RRRRSRTFSRSSSHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCV
DHRRGGTQVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCI
SFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNS
DYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQP
CDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPVPSRMIRKTRKQKYFYRGRLDW
DENTSAGRYVRENCKPLRRYLTSEAEDHHQLFDLIENMLEYEPAKRLTLGEALQHPFFAC
LRTEPPNTKLWDSSRDISR
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BDBM50292406 |
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n/a |
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Name | BDBM50292406 |
Synonyms: | CHEMBL485053 | leucettamine B |
Type | Small organic molecule |
Emp. Form. | C12H11N3O3 |
Mol. Mass. | 245.234 |
SMILES | CN1C(N)=NC(=Cc2ccc3OCOc3c2)C1=O |w:6.6,c:3| |
Structure |
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