| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2C9 |
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| Ligand | BDBM50399012 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_874072 (CHEMBL2186605) |
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| IC50 | >10000±n/a nM |
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| Citation |  Hanan, EJ; van Abbema, A; Barrett, K; Blair, WS; Blaney, J; Chang, C; Eigenbrot, C; Flynn, S; Gibbons, P; Hurley, CA; Kenny, JR; Kulagowski, J; Lee, L; Magnuson, SR; Morris, C; Murray, J; Pastor, RM; Rawson, T; Siu, M; Ultsch, M; Zhou, A; Sampath, D; Lyssikatos, JP Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors. J Med Chem55:10090-107 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2C9 |
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| Name: | Cytochrome P450 2C9 |
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| Synonyms: | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | CP2C9_HUMAN | CYP2C10 | CYP2C9 | CYPIIC9 | Cytochrome P450 2C9 (CYP2C9 ) | Cytochrome P450 2C9 (CYP2C9) | P-450MP | P450 MP-4/MP-8 | P450 PB-1 | S-mephenytoin 4-hydroxylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 55636.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11712 |
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| Residue: | 490 |
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| Sequence: | MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV
YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM
KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID
LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK
KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP
PFYQLCFIPV
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| BDBM50399012 |
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| n/a |
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| Name | BDBM50399012 |
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| Synonyms: | CHEMBL2178250 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H14ClN5O |
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| Mol. Mass. | 363.8 |
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| SMILES | Cc1cc(NC(=O)c2cnn3cccnc23)c(cn1)-c1cccc(Cl)c1 |
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| Structure | 
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